We look at the cutting-edge injectable hydrogel that delivers long lasting, proven pain relief for knee osteoarthritis without surgery(1-4)

For many of the 8.5 million people in the UK living with knee osteoarthritis (OA),(5) life is hampered by constant pain, limited mobility, and difficulty with simple, everyday tasks. But there’s hope with Arthrosamid® – the first and only permanent injectable treatment that is proven to maintain a significant, long-lasting reduction in knee OA pain – even three years post treatment.(1-4) Experts are calling it a ‘game-changer.’

Sufferers delay seeking help for knee pain, assuming it’s an unavoidable part of ageing. But Arthrosamid® offers patients a new pathway. Unlike traditional treatments, it’s proven to offer respite from knee osteoarthritis with a single treatment, and without the need for surgery.(1-4)

Knee OA: common causes and treatments

Great British Life: Arthrosamid® offers patients a new pathway.Arthrosamid® offers patients a new pathway. (Image: AdobeStock)

Knee OA is a long-term condition where shock-absorbing cartilage is worn away, causing bones to rub together and the joint to become stiff, swollen, and painful. Despite OA being the most common type of arthritis and the fastest cause of disability worldwide,(6) the treatment area has seen minimal progression in the last 20 years. With so little known about the exact causes of knee OA, a permanent cure has yet to be discovered.

Many sufferers find themselves in an ongoing cycle of treatments, such as painkillers, physiotherapy appointments and various knee joint injectables (eg steroids or hyaluronic acid).  Despite providing some relief, the effects can often be relatively short-lived, leaving many fearing that knee replacement surgery is the only long-term answer.

The emergence of Arthrosamid®, however, has been hailed by leading clinicians as an exciting, first and only injectable hydrogel that has been proven(7) and offers a real alternative to surgery, helping patients with knee osteoarthritis ‘move freely, live fully’.

What the experts say

Great British Life: Setting a real benchmark in injectables for osteoarthritis of the kneeSetting a real benchmark in injectables for osteoarthritis of the knee (Image: Arthrosamid®)

Mr Amir Qureshi is a specialist consultant knee surgeon from the University Hospital Southampton and Healthshare Clinic, Winchester, one of a number of clinics in Hampshire offering the Arthrosamid® treatment. He is committed to innovative interventions that avoid or delay an eventual knee replacement. He says: “I’m excited to be offering patients the Arthrosamid® treatment. In contrast to other treatments, Arthrosamid® appears to be offering patients long-lasting respite from the pain and immobility of knee osteoarthritis and, in many cases, avoiding or delaying the need for surgery. 

“I believe it’s setting a real benchmark in injectables for osteoarthritis of the knee, offering hope and optimism to many of those living with this condition.”

How does Arthrosamid® work?

Arthrosamid® is a hydrogel made up of 2.5 per cent cross-linked polyacrylamide and 97.5 per cent water. Arthrosamid® combines with the synovial tissue in the knee to form a permanent scaffold,(8) and it’s this unique characteristic that provides a significant reduction in OA pain over a longer period(1-4) — with one single treatment.(7)

To find your nearest clinic offering the Arthrosamid® treatment, please visit arthrosamid.com/patients/get-treated or email; enquiries@arthrosamid.com

To find out more general information about Arthrosamid®, please visit: arthrosamid.com


1. Bliddal, H., et al. (2021) Polyacrylamide Hydrogel Injection for Knee Osteoarthritis: A 6 Months Prospective Study. J Orthop Res Ther. Vol 6 (2). 1188. ISSN 2575-8241 

2. Bliddal, H., et al. (2022). One-year performance of polyacrylamide hydrogel vs. hyaluronic acid: A randomised controlled study. Osteoarthritis and Cartilage, Vol 30, S1, S371.

3. Bliddal, H., et al. (2023) A Prospective Study of Polyacrylamide Hydrogel Injection for Knee Osteoarthritis: Results From 3 Years After Treatment. Osteoarthritis and Cartilage. Vol 31(5): 682-683.

4. Bliddal, H., et al. (2024) 3-year follow-up from a randomized controlled trial of intra-articular polyacrylamide hydrogel injection in subjects with knee osteoarthritis. Poster LB-31, OARSI 2024 World Congress on Osteoarthritis.

5. nice.org.uk/guidance/cg177/documents/osteoarthritis-update-final-scope2

6. Neogi, T. (2013) The epidemiology and impact of pain in osteoarthritis. Osteoarthritis and Cartilage. Vol 21 (9): 1145-53. DOI:10.1016/j.joca.2013.03.018. 

7. Arthrosamid®, Instructions For Use. Release Date March 2022 10082-003

8. Christensen, L., et al. (2016). Histological Appearance of the Synovial Membrane after Treatment of Knee Osteoarthritis with Polyacrylamide Gel Injections: A Case Report. Journal of Arthritis. Vol 5: 217.